Ionotropic glutamate-like receptor 2 binds D-serine and glycine
نویسندگان
چکیده
*Biostructural Research Unit, Department of Medicinal Chemistry, and §Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; †Department of Molecular Neurobiology, Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark; and ‡Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322
منابع مشابه
The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region
Ionotropic glutamate receptors (iGluRs) are responsible for most of the fast excitatory communication between neurons in our brain. The GluD2 receptor is a puzzling member of the iGluR family: It is involved in synaptic plasticity, plays a role in human diseases, e.g. ataxia, binds glycine and D-serine with low affinity, yet no ligand has been discovered so far that can activate its ion channel...
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